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Christina Applegate Says ‘I Live Kind of in Hell’ Amid Multiple Sclerosis Diagnosis

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Christina Applegate is opening up about living with multiple sclerosis on “Good Morning America” in her first on-camera sit-down interview following her 2021 diagnosis.

“I live kind of in hell,” Applegate told host Robin Roberts in a clip of the interview teased on “GMA” Monday morning. “I’m not out a lot, so this is a little difficult, just for my system. But of course, the support is wonderful and I’m really grateful.”

Applegate participated in the interview — which airs in full on Tuesday — alongside “The Sopranos” star Jamie-Lynn Sigler, who has been fighting MS since she was 20 years old.

In January, Applegate received a standing ovation when she was a surprise presenter at the Emmys. “We don’t have to applaud every time I do something,” Applegate quipped as the audience roared with applause.

Of the Emmys moment, Applegate admitted that she “actually kind of blacked out.”

“People said, ‘Oh you were so funny,’ and I’m like, ‘I don’t even know what I said,’” Applegate said. “I don’t know what I was doing. I got so freaked out that I didn’t even know what was happening anymore. And I felt really beloved, and it was a beautiful thing.”

Applegate said in May 2023 that she likely wouldn’t appear on-camera anymore due to the autoimmune disease.

“I’m probably not going to work on-camera again, but I’m so glad that I went out with someone who is by far the greatest actress I’ve ever worked with in my entire life, if not the greatest human I’ve ever known,” Applegate told Vanity Fair of her “Dead to Me” co-star Linda Cardellini.

She added, “I can do voiceover stuff because I have to support my family and keep my brain working.”

The full interview with Applegate and Sigler airs on “Good Morning America” on Tuesday.